![]() These advances promise to have a powerful impact on fundamental as well as clinical studies. Functional OCT promises to enable the differentiation of retinal pathologies via localized, functional retinal response or metabolic properties. In addition, extensions of OCT have been developed to enhance image contrast and to enable non-invasive depth-resolved functional imaging of the retina, thus providing blood flow, spectroscopic, polarization-sensitive and physiological information. Adaptive optics using high-stroke, deformable mirror technology to correct higher order aberrations in the human eye, in combination with specially designed optics to compensate chromatic aberration along with three-dimensional UHR OCT, has recently enabled in vivo cellular-resolution retinal imaging. The development of broadband light sources emitting at new wavelengths, e.g., approximately 1050 nm, has enabled not only 3D-OCT imaging with enhanced choroidal visualization, but also reduced scattering losses and improved OCT performance in cataract patients. High-speed imaging facilitates the acquisition of three-dimensional data sets (3D-OCT), thus enabling volumetric rendering and the generation of OCT fundus images that precisely and reproducibly register OCT images to fundus features. Three-dimensional, ultrahigh-resolution OCT (UHR OCT) can provide information on intraretinal morphology that is not available from any other non-invasive diagnostic. ![]() The development of ultrabroad-bandwidth and tunable light sources, as well as high-speed Fourier detection techniques, has enabled a significant improvement in ophthalmic optical coherence tomography (OCT) imaging performance. In vivo retinal optical coherence tomography at 1040 nm-enhanced penetration into the. W Drexler, U Morgner, RK Ghanta, FX Kärtner, JS Schuman, JG Fujimoto. OCT functions as a type of optical biopsy, providing information on retinal pathology in situ and in real time, with resolutions approaching that of excisional biopsy and histopathology. -resolution ophthalmic optical coherence tomography. ![]()
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